Processing technologies all from one source

Tablettencoater TP R Optima von Romaco Tecpharm (Bildnachweis:Romaco Group) / TP R Optima tablet coater from Romaco Tecpharm (Photo: Romaco Group)

Wirbelschichtprozessor VENTILUS® Pilot von Romaco Innojet (Bildnachweis:Romaco Group) / VENTILUS® Pilot fluid bed processor from Romaco Innojet (Photo: Romaco Group)

Einfachrundläuferpresse KTP 590X von Romaco Kilian (Bildnachweis:Romaco Group) / KTP 590X single-sided rotary press from Romaco Kilian (Photo: Romaco Group)

Romaco will take advantage of this year’s CPhI Worldwide in Milan (Italy) to show its processing portfolio for granulation, tableting and coating of pharmaceutical solids and present itself as a single-source supplier. What’s more, the TP R Optima from Romaco Tecpharm will be making its live debut at a trade show. This tablet coater convinces with fully automatic adjustment of batch sizes from 10 to 100 percent.

TP R Optima tablet coater from Romaco Tecpharm

The TP R Optima perforated coating pan from Romaco Tecpharm genuinely processes any batch size from 10 to 100 percent with one and the same drum and achieves optimum coating results, no matter how small the filling volume. Its wide range of applications is the outcome of the full automation of the tablet coater with its GMP-compliant in-wall design. An extendable spray arm with movable spray nozzles ensures not only the correct spray distance but also the ideal spray angle. Both the batch volume and the tablet bed inclination, which varies according to the turning speed of the pan drum, are measured continuously using sonar technology. The patented spray system is thus capable of aligning the nozzle distance and angle automatically throughout the entire process. Furthermore, air exhaust flaps that can be opened steplessly allow exact adjustment of the air path inside the drum. This precise flow control provides loss-free application of the coating suspension and efficient drying of the tablet bed. Apart from shorter processing times, this simultaneously reduces energy consumption and cuts coating liquid usage by up to 60 percent. In short, the TP R Optima supports sustainable production of pharmaceuticals and nutraceuticals. Last but not least, Romaco Tecpharm’s smart coating technology includes a system for detecting and accurately identifying blocked spray nozzles.

VENTILUS® Pilot fluid bed processor from Romaco Innojet

The VENTILUS® Pilot fluid bed processor from Romaco Innojet is a mobile all-rounder for pilot scale applications or small batches. The technology impresses with excellent results in terms of flow properties as well as powder and granulate compressibility. 100 percent natural granulation is now possible without any chemical additives. Mounted on four wheels, this compact machine fits through any standard door frame and is designed for plug & play installation. An all-in-one solution intended for batch sizes from 4 to 25 litres, it granulates, dries or coats particles of any size from 10 μm to 2 mm. The technology meets all the requirements for laboratory use as well as for GMP-compliant production of clinical samples. The spray liquid is applied with the central ROTOJET® nozzle using a bottom spray system or alternatively by means of the conventional top spray method. The cylindrical container featuring the ORBITER® booster permits controlled, gentle batch intermixing. The homogeneous flow conditions improve product quality and reduce the spray liquid consumption while simplifying scale-ups. In addition, the VENTILUS® Pilot is suited for hot melt coating processes, which merely requires connection of the patented Innojet IHD hot melt system. The processing time is consequently up to 85 percent shorter and the processor’s carbon footprint is significantly lower.

KTP 590X single-sided rotary press from Romaco Kilian

The KTP 590X is a single-sided, versatile rotary press which is used to manufacture both mono-layer and bi-layer tablet formats. Three pairs of compression rollers allow the machine to be changed over between mono-layer and bi-layer mode without time-consuming conversion of the compression stations. The single-sided rotary press reaches a maximum total output of 511,200 tablets per hour. The fill shoe distributes the powder absolutely uniformly in the die. Thanks to the optimised paddle design, even poorly flowing or sticky powders can be processed without any problem and compressed homogeneously. The Kilian KTP 590X is therefore ideal for manufacturing effervescent tablets. In this case, the powder is simply tamped initially, then pre-compressed and finally converted into finished tablets in the main compression unit – air pockets and the resulting capping are thus prevented. The dwell time is significantly longer owing to the use of Kilian 28/41 tooling, meaning harder tablets can be made and product quality improved. Patented bellows moreover protect the tablets from contamination in the form of black spots. The KTP 590X stands for low process temperatures, efficient cleaning and retooling and a mature hygiene concept – in conformity with the design principles of Romaco Kilian’s KTP product family: “Cool, Fast & Clean”.