Virtual Show: new technologies for solid dosage forms from Syntegon

Anlässlich der Virtual Show führt Syntegon die neue Sepion Coater-Baureihe im Markt ein. Das hochmoderne Equipment für die Tablettenbeschichtung wird künftig in sechs Größen verfügbar sein. / At the Virtual Show, Syntegon introduces the new Sepion coater series to the market. The state-of-the-art equipment for tablet coating will be available in six different sizes.

Besucher der Virtual Show von Syntegon erfahren, wie die Xelum R&D absatzweise einzelne Pakete, sogenannte X-Keys, kontinuierlich dosiert, mischt und granuliert und anschließend pneumatisch in die GKF 720 Kapselfüllmaschine fördert. / Visitors to the Virtual Show can find out how the Xelum R&D doses, mixes and granulates individual packages, so-called X-keys continuously and conveys them pneumatically into the GKF 720 capsule filling machine.

Das neue, von Syntegon entwickelte, „Automated Process Development“ (APD) Tool ermittelt die optimalen Prozessparameter beim Kapselfüllen. Das sorgt für ein besseres Prozessverständnis und letztlich eine höhere Produktqualität. / The new “Automated Process Development” (APD) tool developed by Syntegon Technology determines the optimum process parameters for capsule filling, ensuring a better process understanding and ultimately leads to higher product quality.

- Market launch: new Sepion Coater series in six sizes
- Continuous production from powder to capsule
- New APD tool determines optimum process parameters for capsule filling

From May 7 to 13, Syntegon Technology showcases its long-standing processing and packaging expertise for solid dosage forms at the Virtual Show. The new Sepion coater series, which is available in six sizes, marks the beginning of the novelties. Visitors to the virtual event can also experience continuous production from powders to the finished capsule with the specially developed X-key principle. In addition, the new "Automated Process Development" (APD) tool automatically calculates optimal parameters for capsule filling processes in very short times.

New coater series combines experience and innovation

Syntegon presents its new Sepion coater series for the first time. "We have combined decades of experience of the former Manesty product brand with the expertise in tablet coating and process technology of the Hüttlin product brand. By introducing the new Sepion series we can offer our customers an ideal combination of experience and innovation", says Fritz-Martin Scholz, product manager at Syntegon. The state-of-the-art equipment for tablet coating enables closed material handling during filling, sampling and emptying. This makes the Sepion coaters suited for the coating of tablets with highly potent active ingredients, as well as for sugar coating. The optimized drum geometry with its sophisticated spraying system offers better guidance of the process air and shorter processing times. Moreover, the coaters feature an automatically adjustable spray arm and ensure high flexibility from 10 to 100 percent batch size. The fully equipped Sepion coaters are available in six sizes: from 175 and 250 to 350 and 500 to 750 and 1,000 liters capacity.

Continuous Manufacturing with the X-key approach

The continuous production of oral solid dosage forms is an unbroken trend. The Xelum production platform and Xelum R&D unit are based on the same principle developed by the Hüttlin product brand: as opposed to the common complex mass flow rate, excipients and active ingredients are dosed as a discrete mass. This makes it possible to dose even smallest amounts of APIs of less than one percent reliably. At the Virtual Show, visitors can find out how the Xelum R&D doses, mixes and granulates individual packages, so-called X-keys. The packages continuously run through the process chain and are pneumatically transported to the GKF 720 capsule filling machine and filled into capsules.

APD: optimum parameters for capsule filling processes

As another highlight, Syntegon Technology presents a number of new software features, including the "Automated Process Development" (APD) tool to determine optimum parameters for capsule filling processes. "While such manual evaluations used to take days or even weeks, the APD tool not only achieves faster but also more precise results”, Matthias Mössinger, Product Manager at Syntegon Technology, explains. By determining correlations between parameters critical to material, quality and processes, the tool ensures a better understanding of the process – which in turn has a positive effect on product quality. "Investments in tools such as the APD during the process development phase will definitely be rewarded in commercial production", Mössinger says. In the future, the APD tool will be available for both capsules and tablets.

Line competence for solid pharmaceuticals

Additionally, Syntegon offers customers machines and lines for secondary packaging of their solid pharmaceuticals, as well as comprehensive Track & Trace solutions. The portfolio is rounded off by comprehensive services along the entire machine life cycle.

Visit Syntegon Technology's Virtual Show from May 7 to 13 and learn more about the novelties: www.syntegon.com