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All publications from Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Messung des Motorprotein Kinesin-1 (rot), wie es auf den Mikrotubuli (weiß) entlang „läuft“. Die Beobachtung der 2D-Bewegungen einzelner Kinesin-1-Dimere (auf der Skizze in verschiedenen Farben) unter physiologischen ATP-Konzentrationen zeigt auf, wie sie entlang einzelner Bahnen voranschreiten. MINFLUX erfasst dabei bisher unerkannte Details der Bewegung des Motorproteins auf einzelnen Protofilamenten des Mikrotubulus (grau skizziert) und unterstreicht so das Potenzial von MINFLUX als revolutionäre Methode zur Beobachtung von Konformationsänderungen in Proteinen. (Bild: MPI für medizinische Forschung) / Detailed measurement of how the motor protein kinesin-1 (red) walks on microtubules (white). Tracking of the 2D movements of individual kinesin-1 dimers (color coded on the sketch) at physiological ATP concentrations revealed key details of how the protein walks in individual lanes. MINFLUX facilitated near protofilament tracking of the motor protein on the microtubule (sketched in grey) and highlights the effectiveness of MINFLUX as a tool for monitoring conformational changes in proteins. (Photo: MPI for Medical Research)
  • Devices

Pushing the MINFLUX technique to higher spatial and temporal precision allows protein dynamics to be observed under physiological conditions

Fast even at the nanometer level: major advance in super-resolution fluorescence microscopy

Scientists led by Nobel Laureate Stefan Hell at the Max Planck Institute for Medical Research in Heidelberg have developed a super-resolution microscope with a spatio-temporal precision of one nanometer per millisecond. An improved version of their recently introduced MINFLUX super-resolution micros…

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